Natiijooyinka cilmi-baaris cusub oo lagu daabacay joornaalka Biomed Central BMC waxay muujisay in laga soosaaray turmeric uu waxtar u leeyahay sida paracetamol si loo yareeyo xanuunka iyo calaamadaha kale ee osteoarthritis jilibka (OA).Daraasadu waxay muujisay in xarunta bioavailable ay waxtar badan u leedahay dhimista bararka.
Lafo-jileecu waa cudur ba'an oo ku dhaca kala-goysyada articular ee lagu garto burburka carjawda, xuubka xubnaha, seedaha, iyo lafaha hoose.Calaamadaha caadiga ah ee osteoarthritis waa qallafsanaan iyo xanuun.
Waxaa hogaaminaya Shuba Singhal, PhD, daraasaddan la kala soocay, ee la xakameeyey ee kiliinikada waxaa lagu qabtay Waaxda Lafaha ee Lok Nayak Jai Prakash Hospital/Maulana Azad Medical College, New Delhi.Daraasada, bukaanada 193 ee laga helay osteoarthritis ee jilibka ayaa la kala soocay si ay u helaan mid ka mid ah soosaarida turmeric (BCM-95) sida 500 mg capsule laba jeer maalintii, ama 650 mg oo kiniin ah oo paracetamol ah saddex jeer maalin kasta lix toddobaad.
Calaamadaha xanuunka jilibka ee xanuunka, qallafsanaanta wadajirka ah, iyo shaqada jirka oo yaraaday ayaa lagu qiimeeyay iyadoo la adeegsanayo Western Ontario iyo McMaster Universities Osteoarthritis Index (WOMAC).Lix toddobaad oo daaweyn ah ka dib, falanqaynta jawaab-bixiyeyaashu waxay muujisay horumar la taaban karo oo ku yimid buundooyinka WOMAC ee dhammaan cabbirrada la barbar dhigo kooxda paracetamol, iyadoo 18% kooxda BCM-95 ay soo sheegeen 50% horumar, iyo 3% maadooyinka tilmaamaya 70% horumar.
Natiijooyinkan ayaa si togan uga muuqday kooxda BCM-95 ee calaamadaha caabuqa serum: Heerarka CRP waxaa la dhimay 37.21%, iyo heerarka TNF-α waxaa la gooyay 74.81%, taasoo muujinaysa BCM-95 ay samaysay si ka fiican marka loo eego paracetamol.
Daraasadu waxay daba socotay daraasad Arjuna ah oo la sameeyay sanad ka hor taas oo muujisay xidhiidh togan oo u dhexeeya qaabaynta curcumin-ga calanka iyo daryeelka osteoarthritic.
"Hadafka daraasadda hadda jirta waxay ahayd in la dhiso daraasadihii hore si loo bixiyo caddayn wanaagsan oo gaar ah iyada oo lagu daro calaamado badan iyo habka dhibcaha wanaagsan," ayuu yiri Benny Antony, maamulaha guud ee Arjuna."Saamaynta anti-arthritic ee BCM-95 ee osteoarthritis waxaa loo aaneynayaa awoodda ay u leedahay inay wax ka beddesho calaamadaha caabuqa ee TNF iyo CRP."
Jilibka OA waa sababta ugu badan ee naafanimada iyo xanuunka ee dadka waaweyn iyo dadka da'da ah.Qiyaastii 10 ilaa 15% dhammaan dadka qaangaarka ah ee da'doodu ka weyn tahay 60 sano waxay leeyihiin shahaado OA ah, oo ay ku badan yihiin dumarka marka loo eego ragga.
"Daraasaddani waxay dib u xaqiijinaysaa saameynta anti-arthritic ee BCM-95 waxayna bixisaa rajo cusub oo malaayiin ah si ay u wanaajiyaan tayada noloshooda," ayuu yiri Nipen Lavingia, lataliyaha hal-abuurka ee Arjuna Natural oo ku salaysan Dallas, TX.
"Waxaan wax badan ka baraneynaa hababka ka dambeeya curcumin's saameynta anti-bararka taas oo aan aaminsanahay inay tahay natiijada awoodda ay u leedahay inay joojiso calaamadaha pro-bararka, sida prostaglandins, leukotrienes, iyo cyclooxygenase-2.Intaa waxaa dheer, curcumin ayaa la soo bandhigay si loo xakameeyo dhowr cytokines pro-bararka iyo dhexdhexaadiyeyaasha sii deyntooda, sida buro necrosis factor-α (TNF-α), IL-1, IL-8, iyo nitric oxide synthase, "ayuu yiri Antony.
Fiyuuska BCM-95 ee u gaarka ah ee curcuminoids iyo qaybaha saliidda lagama maarmaanka ah ee qani ku ah turmerone waxay ka adkaataa curcumin sifada bioavailability caqabadaha sababtoo ah dabeecadeeda sare ee lipophilic.
Waqtiga boostada: Abriil-12-2021